Acylated pregnane glycosides from Caralluma tuberculata and their antiparasitic activity.
نویسندگان
چکیده
Five pregnane glycosides were isolated from Caralluma tuberculata (1-5), in addition to a known one (russelioside E, 6). The structures of the isolated compounds were elucidated by the analysis of NMR data and FAB-MS experiments. All the isolated compounds were tested for their antimalarial and antitrypanosomal activities as well as their cytotoxicity against human diploid embryonic cell line (MRC5).
منابع مشابه
Antitrypanosomal activity of some pregnane glycosides isolated from Caralluma species.
Pregnane glycosides previously isolated from genus Caralluma (C. Penicillata, C. tuberculata and C. russelliana) were tested for their antitrypanosomal activity. Penicilloside E showed the highest antitrypanosomal activity (IC(50) 1.01 microg/ml) followed by caratuberside C (IC(50) 1.85 microg/ml), which exhibited the highest selectivity index (SI 12.04). It was noticed that acylation is requir...
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ورودعنوان ژورنال:
- Phytochemistry
دوره 69 11 شماره
صفحات -
تاریخ انتشار 2008